What is the best match for the route "Otic"?

The term "otic" specifically refers to something related to the ear. In pharmacology, otic preparations are designed for direct application into the ear canal, typically to treat conditions such as infections or inflammation. This route of administration allows for localized treatment of ear-related issues by delivering the medication directly to the site where it is needed most.

In contrast, the other options refer to different anatomical locations and routes. Medications that are applied "in a vein" pertain to intravenous administration, which is not relevant to otic use. Similarly, applications "on the skin" correspond to topical treatments, and "eye" refers to ocular medications, both of which are distinct from otic applications. Understanding these terms helps clarify the specific use and application of various medicinal routes.