Which principle explains Connor's need to discuss a medication alternative after five years of ineffective pain management?

The principle that best explains Connor’s need to discuss a medication alternative after five years of ineffective pain management is tolerance. Tolerance develops when a person’s response to a drug diminishes over time, leading to a reduced effect of the medication for the same dosage. In Connor's case, if he has been on the same pain management medication for five years without sufficient relief, it is likely that his body has built up a tolerance, requiring either a dosage increase or a switch to a different medication to achieve the desired therapeutic effect.

In the context of pain management, patients often find that medications become less effective after prolonged use, prompting healthcare providers to reassess treatment plans. This principle highlights the importance of monitoring patient responses and being prepared to adapt treatment strategies over time, particularly for chronic conditions.